Record Details     « New Search       Brief Record Full Record MARC Record     Bibliographic Data Control Number 370904 Date and Time of Latest Transaction 20201212060927.AM General Information 201212s |||||||||b ||00||| Cataloging Source DOST-PCHRD Main Entry - Personal Name Dela Cruz, Rowell Anthony B.   De Guzman, Patrina D.   Cayanan, Catherine G.   Mendoza, Margarita U.   Ramos, Karla Paula I.   Sanguyo, Analiza L. Title Statement Anti-inflammatory and diuretic activity of resin from kapok (Ceiba pentandra Linn. Family bombacaceae Physical Description 0 Summary, Etc. The Problem: This study deals with the determination of the Anti-Inflammatory and Diuretic activity of resins from the bark of kapok, scientifically known as Ceiba pentandra Linn, family Bombacaceae. Subproblems: 1. How will the barks of the plant be collected and prepared? 2. How will the preliminary test for resins be conducted? 3. What is the method used in the extractionand purification of resins? 4. What are the physical and chemical properties manifested by resins extractives? 5. How will the anti-inflammatory activity of the resin from the bark of the plant sample be investigated? 6. How will the diuretic activities of the resin from the bark of the kapok determined? Method Used: Experimental Method Location: Centro Escolar University Library Medicinal Plants are of great economic importance. They are used as raw materials for the extraction of active constituents in pure form, as a precursor for synthetic vitamins, and steroids, and as preparations for herbal and indigenous medicines. Furthermore, the Philippine flora is a vast source of potential medicinals. Thus, medicinal plants have been an integral part of the Philippine way of life for many years. The researchers aimed to give more knowledge about the potential curative values of Kapok tree that are commonly found in settled areas throughout the Philippines and also in other countries. In line with goal of the researchers, the study will deal with one of the most abundant plants in the country. The Kapok tree, scientifically known as Ceiba pentandra Linn (Bombacaceae), is widely spread around the world and occupies an important niche in the ecosystem of a rainforest. The plant Ceiba pentandra (Linn)was introduced from Tropical America and is cultivated in settled areas throughout the Philippines and is now pantropic in distribution. Kapok is an erect decidous tree 15 meter or less in height. The trunk is cylindric, usually bearing scattered, large spines. The branches are in distant whorls and spread horizontal. The leaves are compound with pointed at the ends. The flowers are numerous, whitish and 3 centimeter long. The capsules are pendulous oblong, about 15 centimeter lenght and 5 centimeter thick. They contain numerous black seeds that are compressed-globose, smooth and embedded in rine, silkyhairs. One of the active constituents of Kapok, which is proven to be present, based on phytochemical screening is resin. Wherein resin is term applied to a group of sticky, liquid, organic substances that usually harden, upon exposure to air, into brittle, amorphous, solid substances. The barks of Kapok were collected in the province of Bulacan, specifically in Barangay Sto. Nino, Plaridel during the months of July and August. It was gathered, cleansed and cut into small pieces, and then allowed to be air-dried to remove the moisture content of the Kapok bark and were further dried in an oven at 60 degrees Centigrade. Then, about 50g of the plant sample were placed in an Erlenmeyer flask and a sufficient 80% ethyl alcohol was added. The sample was macerated for two to three days and it was then filtered. The filtrate was evaporated into incipient dryness and undergone the Phloroglucinol Test to determine the presence of resins. n the other hand the small pieces of dried bark were maacerated with 95% ethyl alcohol for 48 hours and refluxed for two to three hours until the plant sample was fully exhausted. The extract was filtered and evaporated until a syrupy consistency is obtained. It was purified with 1% Hydrochloric acid and distilled water. These resins had undergone the physical and chemical test such as organoleptic evaluation and solubility test and Phloroglucinol, Smoky Flame test and Acid Value. After the physical and chemical test the biological test were done using the Carrageenan-induced Edema Method for the Anti-Inflammatory test and the Rat Metabolic Cage Method for the diuretic test. The percentage yield was calculated and it yielded 0.68%. The Carrageenan-Induced Edema Method for the anti-inflammatory test for the isolated resins gave a positive percentage inhibition of 58.14% at 500mg/kg and 62.79% 1000 mg/kg. Wherin it gave a negative percentage inhibition at 250 mg/kg dose giving a 4.65% inhibition. In the Rat Metabolic Cage Method, the dose of 250 mg/kg yielded 366.67%, 500 mg/kg exhibited 333.33% and 1000 mg/kg yielded266.67% increase in urine volume, showed effectiveness as a diuretic agent. Based on the experimental results obtained from the study of resins, the conclusion drawn are: The Kapok bark contains resins. The rein extractive exhibited a significants role as an anti-inflammatory drug. The higher the dose of the resin extract, the greater the effectiveness of its as an anti-inflammatory agent. Based on the gathered data the researchers proved that 1000 mg/kg dose is almost as effective as Aspirin. It is also has a potential diuretic agent. And the recommendations of the researchers are the following: further pharmacological studies on the different parts of Kapok plant must be conducted for the determination of other active constituents and different therapeutic activities present in the plant.A study on the toxicity levels such as LD50 and ED50 for Kapok bark. Perform FTIR for functional group and Nuclear Magnetic Resonance for Identification of structural formula of resin. Development of dosage forms for anti-inflammatory and diuretic. Continous propagation of the Kapok plant for further studies Subject Added Entry - Topical Term ANTI-INFLAMMATORY AGENTS   DIURETICS   CEIBA   BOMBACACEAE   DIURETIC ACTIVITY   RESIN   KAPOK TREE   BARK   CEU   CEIBA PENTANDRA   EXPERIMENTAL STUDY   ANTI-INFLAMMATORY AGENTS   DIURETICS   CEIBA   BOMBACACEAE           Physical Location           Digital Copy Not Available          Add to Book Cart  |   Download MARC