Record Details     « New Search       Brief Record Full Record MARC Record     Bibliographic Data Control Number 407973 Date and Time of Latest Transaction 20201212061610.AM General Information 201212s |||||||||b ||00||| Cataloging Source DOST-PCHRD Main Entry - Personal Name Raymundo, Maria Fe P. Title Statement An investigative and comparative study on the hypoglycemic effects of momordica charantia (ampalaya) and aloe vera (sabila) Physical Description 10-18 Summary, Etc. Objective: To investigate the hypoglycemic properties of Ampalaya and Sabila compared to Insulin and to determine which of them has a greater blood glucose-lowering effect. Design: Baseline blood sugar levels (BSL) were determined for all test animals (40 Swiss mice) after 12 hours of fasting and were recorded as the FBS. Hyperglycemia was induced by suncutaneous injection of Alloxan monohydrate (125 mg/100 gm BW) followed by intraperitoneal injection of 50% Glucose solution, after another 12 hours. Blood sugar levels recorded after 1 hour were taken as the hyperglycemic state. The animals were given the test plants: agueous solution of Ampalaya fruit (1.5 mg/kg) PO, and decoction of dried sap of Aloe vera (500 mg/kg) PO, and the standard drug insulin SC (2U/kg) for the positive and distilled water PO for the negative control groups. respectively. Blood sugar levels were determined 1 hr, 2hrs., 3 hrs., and 4 hrs. after induction of hyperglycemia. Descriptive statistics was used to determine if the test plants have blood glucose-lowering capacity comparable to insulin, and if such, which of the two has a more significant hypoglycemic effect. Subjects: 40 healthy Swiss mice (20 males and 20 females), 6-8 weeks old, weighing 22-28 grams, s, purchased one week prior to the start of the experiment. Results: There was a significant drop in blood glucose levels for those treated with Ampalaya decoction from the first to the fourth hour, though comparable to insulin effect only on the first and second hours. Aloe vera did not lower down the blood sugar level on the first hour. But there was a significant decrease from the second to the fourth hour, though comparable to insulin effect only on the third hour. There was no significant difference in the maximum change in blood sugar levels from the hyperglycemic state for both test plants. Conclusion: Both Ampalaya and Aloe vera has blood glucose-lowering effects comparanle to Insulin and are both promising antidiabetic agents in the future. Statement of Problem Under Investigation: Do the Ampalaya and Sabila exhibit hypoglycemic properties comparable to a standard antidiabetic drug (Insulin)? And if such, which of the two has a greater blood sugar-lowering effect? Subject Added Entry - Topical Term MOMORDICA CHARANTIA, ALOE, HYPOGLYCEMIC AGENTS   MOMORDICA CHARANTIA, ALOE, HYPOGLYCEMIC AGENTS           Physical Location           Digital Copy Not Available          Add to Book Cart  |   Download MARC