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Bibliographic Data
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409434
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20201212061611.AM
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201212s |||||||||b ||00|||
040
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$aDOST-PCHRD
100
1#
$aMagsakay, Nellie B.
100
1#
$aTuazon, Catherine Hubilla
100
1#
$aReyes, Elizabeth R.
245
00
$aAn evaluation of the effect of chrysophyllum cainito on intestinal motility through charcoal tracing method
300
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$a21-35
504
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$aExperimental Study
520
3#
$aThis experimental study investigated on the effect of Chrysophyllum Cainito (Caimito) leaf extract on the intestinal motility of white mice. The study was done at the MCU-FDTMF College of Medicine, Department of Pharmacology mini laboratory. Leaf extract was obtained thru Reflux Extraction Method. Distilled water then added to the extract in order to obtain the desired concentration. Initially, one hundred forty two (142) mice were studied. However eleven mice could not be evaluated. The 131 mice studied were divided into 5 treatment groups and were given the following doses, (a) 3.0 gram leaf extract/kg mouse (b) 7.70 grams leaf extract/kg mouse, (c) 19.34 grams leaf extract/kg mouse (d) loperamide at .0052 mgs/20 gm mouse, (e) NSS. The mice were fasted for 16 hours and the different treatments were given orally via gavage needle connected to a tuberculin syringe. Activated charcoal was given to each mouse 1 hour after application. Thirty minutes after each mouse was killed and dissected exposing the stomach and intestines. The total length of the mouse small intestine was initially measured and then distance travelled by the activated charcoal was measured from pylorus to the cecum. From this, the percentage of the distance travelled was then computed. The data were gathered and then computed using the STATA to perform Analysis of Variance (ANOVA), specifying randomized complete block design with replicates. The result showed that there is a significant difference between treatment groups (p=0045). To determine which of the groups differ from each other, the Sidak Multiple Comparison Procedure was used. The result showed that the test drugs were not statistically different from the positive control in terms of its antimotility effect but the effective antimotility dose were manifested in the medium and high doses (p=.0029 and p=.0099) respectively.
650
04
$aPLANTS, MEDICINAL
650
04
$aDRUG EVALUATION, PRECLINICAL
650
04
$aGASTROINTESTINAL MOTILITY
650
04
$aCHRYSOPHYLLUM CAINITO
650
04
$aCAIMITO
650
04
$aPLANTS, MEDICINAL
650
04
$aDRUG EVALUATION, PRECLINICAL
650
04
$aGASTROINTESTINAL MOTILITY
991
##
$wANALYTICS
 
     
 
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