Record Details     « New Search       Brief Record Full Record MARC Record     Bibliographic Data Control Number 336094 Date and Time of Latest Transaction 20180924110052.AM General Information 180924s |||||||||b ||00||| Cataloging Source STII-DOST Language Code eng Local Call Number Fil(S) QD1 C416 Main Entry - Personal Name Tamayo, Teresita A.   del Mundo, Florian R.   Cada, Leonorina G.   dela Cruz, Ernesto C. Title Statement A molecularly imprinted polymer stationary phase for chiral separation of ofloxacin by thin layer chromatography by Teresita A. Tamayo, Florian R. del Mundo, Leonorin G. Cada and Ernesto c. dela Cruz Physical Description 53-56 figures, tables Bibliography, Etc. Note Includes bibliographical references Summary, Etc. A molecular imprinting procedure was adopted to prepare a highly crosslinked' polymer for the racemic resolution of ofloxacin, a wide spectrum quinolone anti infective agent. A combination of acidicJUld basic functional monomers, acrylic acid and 4-vinyl pyridine at different proportions, were copolymerized with ethylene glycol dimethacrylate by thermal initiation. These polymers, after drying, sizing, and removal of print molecule,· were used in a batch binding experiment and made into thin layer chromatography (TLC) plates for thin layer chromatographic procedure to examine their enantioselectivityfor levofloxacin or S-Ofloxacin. The results showed that polymer P33 has comparatively 'higher binding capacity and selectivity than the other polymers as far as S-ofloxacin is concerned. This was confirmed by CD-ORD results. This preliminary report demonstrates a novel and promising family of stationary phase (based on predetermined selectivity) for use not only for solid phase extraction but also for liquid' chromatography' and 'capillary electrophoresis;0 Subject Added Entry - Topical Term aChemistry0   aOfloxacin0   aLevofloxacin0   aMolecular imprinting0   aThin layer chromatography0   aChiral separation           Physical Location           Digital Copy Not Available          Add to Book Cart  |   Download MARC