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MARC Record
Bibliographic Data
Control Number
359615
Date and Time of Latest Transaction
20200116100252.AM
General Information
200116s |||||||||b ||00|||
Cataloging Source
STII-DOST
Local Call Number
(T) QK495.E9 E87 2014
Main Entry - Personal Name
Espinosa, Jilly Barimbao
Title Statement
Evaluation of toxicity and antioxidant activity, partial purification and spectroscopic analysis of the bioactive components from the leaves of Cnidoscolus Chayamansa ("Chaya") by Jilly Barimbao Espinosa
Physical Description
xv, 92 leaves figures, tables
Summary, Etc.
The bioactivity of the crude leaf extracts of Cnidoscolus chayamansa (ethanol extract, Cce; hexane extract, CcH; chloroform extract, CcC; aqueous extract CcA; and decoction, CcD) were evaluated using the brine shrimp lethality test and various vitro antioxidant assays (phosphomolybdenum method, DPPH radical scavenging activity, ferric thiocyanate method, and total phenolic contents - Folin Ciocalteu method). The extract CcC exhibited the highest antioxidant activities: 79.70 ppm ascorbic acid equivalence and 79.00 ppm butylated hydroxytolouene equivalence in the phosphomolybdenum method and 97.2% inhibition of lineolic acid peroxidation. The fractionation of the extract CcC yielded eleven fractions (CcC1-CcC11) with fraction CcC3 having the most considerable results toward the various antioxidant arrays. Purification of fraction CcC3 through a series of gravity column chromatography led to the isolation of sub-fraction CcC3.4.6. Analysis of the 1D- and 2D-NMR spectral data (1H, 13C, 1H-1H Homonuclear Correlation Spectroscopy, 1H-13C Heteronuclear Multi-Quantum Correlation, and 1H-13C Heteronuclear Single Quantum Coherence) revealed that sub-fraction CcC3.4.6 is still a mixture. The group of compounds present in fraction CcC3.4.6 includes vinyl, alcohol, ether, and ester groups. The study recommend further purification of the sub-fraction CcC3.4.6, elucidation of their structures and evaluation of their bioactivities
Subject Added Entry - Topical Term
Chemistry
Chaya (Plant)
Tree Spinach
Euphorbiaceae
Location
DOST STII (T) QK495.E9 E87 2014 THESES T STI-17-1518 1 14-19754 Donation 2016-03-05
DOST STII (T) QK495.E9 E87 2014 THESES T STI-17-1554 2 14-19761 Donation 2016-03-05
Physical Location
Department of Science and Technology
Science and Technology Information Institute
(T) QK495.E9 E87 2014
Digital Copy
Not Available
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