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Control Number379750
Date and Time of Latest Transaction20201212061609.AM
General Information201212s |||||||||b ||00|||
Cataloging SourceDOST-PCHRD
Main Entry - Personal NameSolon, Juan Antonio
 Halton, Kate
 Gray, Darren J
 Williams, Gail M
 Yakob, Laith
 Clements, Archie CA
Title StatementSlaving and release in co-infection control
Physical Description157
Summary, Etc.Background Animal and human infection with multiple parasite species is the norm rather than the exception, and empirical studies and animal models have provided evidence for a diverse range of interactions among parasites. We demonstrate how an optimal control strategy should be tailored to the pathogen community and tempered by species-level knowledge of drug sensitivity with use of a simple epidemiological model of gastro-intestinal nematodes. Methods We construct a fully mechanistic model of macroparasite co-infection and use it to explore a range of control scenarios involving chemotherapy as well as improvements to sanitation. Results Scenarios are presented whereby control not only releases a more resistant parasite from antagonistic interactions, but risks increasing co-infection rates, exacerbating the burden of disease. In contrast, synergisms between species result in their becoming epidemiologically slaved within hosts, presenting a novel opportunity for controlling drug resistant parasites by targeting co-circulating species. Conclusions Understanding the effects on control of multi-parasite species interactions, and vice versa, is of increasing urgency in the advent of integrated mass intervention programmes. http://www.ncbi.nlm.nih.gov/ http://www.parasitesandvectors.com/
Subject Added Entry - Topical TermNEMATODE
 MATHEMATICAL MODEL
 INFECTIOUS DISEASE
 EPIDEMIOLOGY
 NEXT GENERATION MATRIX
 DRUG RESISTANCE
 NEMATODE
 MATHEMATICAL MODEL
 INFECTIOUS DISEASE
 EPIDEMIOLOGY
 NEXT GENERATION MATRIX
 DRUG RESISTANCE
 
     
 
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