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MARC Record
Bibliographic Data
Control Number
379750
Date and Time of Latest Transaction
20201212061609.AM
General Information
201212s |||||||||b ||00|||
Cataloging Source
DOST-PCHRD
Main Entry - Personal Name
Solon, Juan Antonio
Halton, Kate
Gray, Darren J
Williams, Gail M
Yakob, Laith
Clements, Archie CA
Title Statement
Slaving and release in co-infection control
Physical Description
157
Summary, Etc.
Background Animal and human infection with multiple parasite species is the norm rather than the exception, and empirical studies and animal models have provided evidence for a diverse range of interactions among parasites. We demonstrate how an optimal control strategy should be tailored to the pathogen community and tempered by species-level knowledge of drug sensitivity with use of a simple epidemiological model of gastro-intestinal nematodes. Methods We construct a fully mechanistic model of macroparasite co-infection and use it to explore a range of control scenarios involving chemotherapy as well as improvements to sanitation. Results Scenarios are presented whereby control not only releases a more resistant parasite from antagonistic interactions, but risks increasing co-infection rates, exacerbating the burden of disease. In contrast, synergisms between species result in their becoming epidemiologically slaved within hosts, presenting a novel opportunity for controlling drug resistant parasites by targeting co-circulating species. Conclusions Understanding the effects on control of multi-parasite species interactions, and vice versa, is of increasing urgency in the advent of integrated mass intervention programmes. http://www.ncbi.nlm.nih.gov/ http://www.parasitesandvectors.com/
Subject Added Entry - Topical Term
NEMATODE
MATHEMATICAL MODEL
INFECTIOUS DISEASE
EPIDEMIOLOGY
NEXT GENERATION MATRIX
DRUG RESISTANCE
NEMATODE
MATHEMATICAL MODEL
INFECTIOUS DISEASE
EPIDEMIOLOGY
NEXT GENERATION MATRIX
DRUG RESISTANCE
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